I will understand you are talking about Golden or Investor Visa (because there are more visas for self-employment). Yes, there are more requirements besides the investment. For example, there is not to have entered or stayed illegally in Spanish territory, not to have been refused entry in any of the Schengen countries, have public or private health insurance authorized to operate in Spain, and have sufficient economic means to cover personal and family living expenses.
What factors to authorities look for when approving a Spanish investor or self-employment visa?
Aside from the financial requirements, I read about Spain requiring a clean medical certificate. How does one obtain those? Are there medical conditions that can preclude applicants from getting approved? Please advise.